Helen Mirren reigns at London's Olivier awards

LONDON (AP) ? Helen Mirren was crowned queen of the London stage at the Olivier Awards Sunday, while compelling, canine-titled teen drama "The Curious Incident of the Dog in the Night-Time" emerged as best in show with seven trophies.

Mirren, 67, was a popular and expected best actress choice for her regal yet vulnerable Queen Elizabeth II in "The Audience," Peter Morgan's behind-palace-doors drama about the relationship between Britain's queen and its prime ministers.

The actress, who won an Academy Award in 2007 for playing Britain's monarch in "The Queen," quipped that it was 87-year-old Elizabeth who deserved an award, "for the most consistent and committed performance of the 20th century, and probably the 21st century."

Backstage, it turned out she wasn't kidding. Mirren, who has been Olivier-nominated three times before, said that finally winning "doesn't mean that I was the best actor. There were so many incredible performances out there."

"I was making a joke about the queen winning, but I think actually it is a reflection of the kind of respect the queen is held in," she said.

Her "Audience" co-star, Richard McCabe, who won the supporting actor trophy for playing 1960s and 70s Prime Minister Harold Wilson, said Mirren was a joy to work with.

"It's important as an actor to be absolutely fearless, and she is," he said.

While the queen herself hasn't been to see the Stephen Daldry-directed show ? rumored to be Broadway-bound ? McCabe said "a lot of people in the royal household have been coming in and watching incognito, and they must be reporting back."

The surprise of the awards ceremony at London's Royal Opera House was "Curious Incident," an adaptation of Mark Haddon's best-selling young-adult novel about a teenage math prodigy with Asperger's Syndrome who sets out to find the killer of his neighbor's dog, with destabilizing results.

The show, which premiered at the state-subsidized National Theatre last year before transferring to a commercial West End playhouse, has won praise for its creative use of movement and technology to make the leap from page to stage.

The Simon Stephens-scripted drama was named best new play, and 28-year-old Luke Treadaway was crowned best actor, beating a strong list of contenders including Rupert Everett, Mark Rylance and James McAvoy.

Treadaway said the "Curious" company knew they had created "something really special" with the show about a teenager "who sees the world differently to a lot of people."

"I think people could kind of see themselves in him," Treadaway said.

"This is not even necessary," he said, holding his trophy, a bust of the late actor Laurence Olivier. "I enjoy doing it so much anyway."

The play also won prizes for director Marianne Elliott and supporting actress Nicola Walker, as well as for set, lighting and sound.

Walker said the play had, through some "magic," succeeded in creating an onstage world as seen through the eyes of a teenage hero with autism.

"You start out thinking (it) is completely different to our world, and you end up thinking 'No, there are parts of this world I understand.'"

The Olivier awards honor achievements in London plays, musicals, dance and opera. Winners in most categories are chosen by a panel of stage professionals and theatergoers.

Founded in 1976, the Oliviers have been laying on the glitz in recent years, with glossy ceremonies modeled on Broadway's Tony Awards.

"Downton Abbey" actor Hugh Bonneville and West End star Sheridan Smith ? an Olivier winner in 2011 and 2012 ? hosted a sparky ceremony that included performances by "Glee" star Matthew Morrison, Tony-winning "Wicked" diva Idina Menzel and 60s songstress Petula Clark.

The best new musical category had a retro feel, with the trophy going to "Top Hat" ? a tap-dancing, tail-coated homage to Hollywood's Golden Age based on the 1935 Fred Astaire-Ginger Rogers movie. It also won awards for costume design and choreography.

Blood-soaked musical "Sweeney Todd" took the prize for best musical revival, with its stars Imelda Staunton and Michael Ball named best actress and actor in a musical.

"I'm not sure I deserve this," Ball said. "But I've also got sciatica, and I don't deserve that either."

Royal Ballet principal dancer Marianela Nunez took the prize for outstanding achievement in dance, while the same company's "Aeternum" was named best new dance production.

An immersive staging of the Philip Glass opera "Einstein on the Beach" at London's Barbican Centre was named best new opera production. American tenor Bryan Hymel won the outstanding achievement in opera prize for performances at the Royal Opera House.

Special achievement awards went to choreographer Gillian Lynne ? best known for her work on Andrew Lloyd Webber musicals including "Cats" and "The Phantom of the Opera" ? and playwright Michael Frayn, whose classic backstage farce "Noises Off" is still going strong 30 years after its debut.

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Jill Lawless can be reached at http://Twitter.com/JillLawless

Online: http://www.olivierawards.com

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/4e67281c3f754d0696fbfdee0f3f1469/Article_2013-04-29-Britain-Theater%20Awards/id-94f604a32597449890990a3b866e4e46

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Conversion from 'bad' fat to good fat

Apr. 28, 2013 ? Scientists from ETH Zurich have shown for the first time that brown and white fat cells in a living organism can be converted from one cell type to the other. Their work, using mice as a model organism, provides important new insights into the origin of brown fat cells, which is a prerequisite for the development of successful anti-obesity therapies.

Two types of fat cells can be found in mammals and hence in humans: White fat cells function mainly as highly flexible energy stores which are filled in times of calorie abundance. The fat is stored in the form of lipid droplets, which are mobilized when energy is needed. Diametrically opposed in function are the so-called brown adipocytes: These cells specialize in burning energy in the form of fat and sugar to produce heat. New-born babies possess substantial amounts of brown fat and utilize it to maintain body temperature. Since it was recently shown that brown adipocytes also exist in adult humans, research has focused on understanding how brown adipocytes are formed. The ultimate goal of these efforts is to increase brown adipocyte number and activity in obese humans, allowing them to burn excess calories and thus reduce weight.

Against the current belief

It is known that both humans and mice can adapt to cold temperatures by forming brown fat cells within their white fat depots. These cells are called "brite" fat cells (brown-in-white) and are less common at warmer versus colder temperatures. However, the origin of these special brown adipocytes has remained a matter of debate. The prevalent hypothesis was that brite cells are formed from special precursor cells and are removed when no longer needed. The alternate idea of a direct interconversion between white and brown fat cells gained less attention. By demonstrating that this interconversion does occur and is one of the main contributors to brite fat cell formation, the current belief has been challenged.

Genetically labelled fat cells

To demonstrate how brite fat cells are formed the researchers in the laboratory of Christian Wolfrum, a professor at the Institute of Food, Nutrition and Health, generated mice that allowed them to genetically label specific fat cells. These animals were kept in a changing environment: starting at 8?C for a week and for several weeks afterwards at normal room temperature. During the cold exposure, the mice formed brown adipocytes in their white fat depots -- a process called "britening." After warm adaptation the fat tissue turned white again. Using the genetic markers the scientists concluded from these experiments that white fat cells can convert into brown fat cells and vice versa. As humans have the same type of cells as mice it is likely that the same process occurs in humans upon cold stimulation.

Treatments against obesity

"To develop new treatment strategies we need to find ways to convert white into brown adipocytes," says Wolfrum. Most of the research has focused on identifying the precursor cells for brown fat cells, an approach that may be insufficient. Future work will address the question of how to manipulate this interconversion process either by pharmacological or by nutritional means.

This approach would represent a novel strategy. "Current anti-obesity therapies target the energy intake side of the equation by controlling appetite and the uptake of nutrients," says Wolfrum. The pharmacological treatments that are available are not very efficient and usually are associated with side effects. In contrast, this novel approach to treat obesity would target the energy expenditure side of the equation by promoting brown fat formation.

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Story Source:

The above story is reprinted from materials provided by ETH Zurich, via EurekAlert!, a service of AAAS.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.

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Journal Reference:

1. Matthias Rosenwald, Aliki Perdikari, Thomas R?licke, Christian Wolfrum. Bi-directional interconversion of brite and white?adipocytes. Nature Cell Biology, 2013; DOI: 10.1038/ncb2740

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/~3/3LfJOKXIqoE/130428144925.htm

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Two police officers shot as Italian government sworn in

ROME (Reuters) - Two police officers were shot and wounded outside the Italian prime minister's office on Sunday as Enrico Letta's new government was being sworn in around a kilometer (mile) away at the president's palace, police and witnesses said.

One man, described by witnesses as well dressed, was arrested at the scene of the shooting where a crowd was waiting for Letta to arrive but it was initially unclear whether the attack was linked to the launch of the new government.

"We still have to understand who he is. He's been caught," Antonio Catricala, a cabinet undersecretary in the former government told reporters.

A police official told Reuters that the man was from the southern region of Calabria and having fired several shots at the two police on duty outside the prime minister's office, he shouted "shoot me, shoot me" to other police nearby.

Letta and his new cabinet were due to come to the prime minister's office to accept a transfer of power from the outgoing government of Mario Monti at 1 p.m. (7:00 a.m. EDT).

One of the officers was shot in the neck and was in a serious condition, a police official said. Another was hit in the leg and was less seriously hurt. Italian media said a passer-by had also been injured but not seriously.

Five or six shots were fired and police had found five spent shells from a small caliber weapon, another official said.

Letta, 46, the moderate deputy head of the Democratic Party (PD), on Saturday ended two months of political stalemate since February's inconclusive election when he brought together former political rivals in a broad coalition government.

Letta's ministers stepped forward one by one to swear allegiance to the republic before President Giorgio Napolitano, who personally picked Letta as prime minister and had a central role in the choice of his cabinet team.

(Reporting by Gavin Jones, Antonella Cinelli, Roberto Landucci; Editing by James Mackenzie and Mark Heinrich)

Source: http://news.yahoo.com/italian-government-under-enrico-letta-sworn-094720376.html

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Time Management For Students > Free Self Improvement Ebook ...

Self Improvement free ebook ?Time Management For Students? covers The Basics On Time Management For Students, Changing Your Mindset About Managing Your Time, Take Inventory Of How You Spend Your Time, Study Habits For Time Management, Managing Work And School, Getting A Grip On School Goals, You May Need To Cut Ties With Some People, Make Sure You Don?t Get Overloaded and The Benefits Of Time Management In School. Personal Use. Click ?Time Management For Students? to download (1 MB zip) or view this free Time Management ebook.

Source: http://free-ebooks-canada.com/?p=6914

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GW Cancer Institute publishes research on challenges faced by adolescent cancer survivors

Public release date: 26-Apr-2013
[ | E-mail | Share ]

Contact: Lisa Anderson
lisama2@gwu.edu
202-994-3121
George Washington University

WASHINGTON (April 26, 2013) New research out of the George Washington University Cancer Institute (GWCI) focuses on the difficulties of transitioning to adulthood while dealing with the long-term and late effects of cancer and its treatment. The study was recently published in the Journal of Oncology Navigation and Survivorship, titled "Improving Cancer Survivorship for Adolescents and Adults."

Based on information obtained at GWCI's second Cancer Survivorship Research Symposium, the paper summarizes the discussion amongst cancer survivors, caregivers, researchers, clinicians and other healthcare professionals. The goal of the symposium was to identify key issues for survivors and strategize about optimal interventions for improving care and support.

The authors outlined five key areas of need related to health care delivery system challenges: psychosocial impacts, health maintenance needs, employment issues and community-level barriers. They explored current approaches for addressing these concerns and made recommendations about interventions that may improve survivorship care and quality of life for adolescents and young adults.

"The symposium was a great opportunity for those within the cancer community to conduct high level conversations about the real needs of adolescent and young adult cancer survivors," said Mandi Pratt-Chapman, M.A., associate director of GWCI Community Programs and author of the study. "Our hope is that we will identify issues and come up with solutions that will address post treatment needs."

###

Additional authors include Anne Willis, M.A., director of the division of cancer survivorship; Jennifer Bretsch, M.S., CPHQ, project manager of the division of cancer survivorship; and Steven Patierno, Ph.D., adjunct professor of pharmacology and physiology at the GW School of Medicine and Health Sciences.

For more information or to interview an author of the study, please contact Lisa Anderson.

About the George Washington University Cancer Institute (GWCI)

GWCI takes a comprehensive approach to a complex disease. In connection with the GW Hospital and the Medical Faculty Associates, GWCI provides for collaboration in the study, diagnosis and treatment of cancer. Its mission is to ensure access to quality, patient-centered care across the cancer continuum through community engagement, patient and family empowerment, health care professional education, policy advocacy and collaborative multi-disciplinary research. More information about GWCI at: gwcancerinstitute.org.

About the GW School of Medicine and Health Sciences

Founded in 1825, the GW School of Medicine and Health Sciences (SMHS) was the first medical school in the nation's capital and is the 11th oldest in the country. Working together in our nation's capital, with integrity and resolve, the GW SMHS is committed to improving the health and well-being of our local, national and global communities. smhs.gwu.edu.

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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

Public release date: 26-Apr-2013
[ | E-mail | Share ]

Contact: Lisa Anderson
lisama2@gwu.edu
202-994-3121
George Washington University

WASHINGTON (April 26, 2013) New research out of the George Washington University Cancer Institute (GWCI) focuses on the difficulties of transitioning to adulthood while dealing with the long-term and late effects of cancer and its treatment. The study was recently published in the Journal of Oncology Navigation and Survivorship, titled "Improving Cancer Survivorship for Adolescents and Adults."

Based on information obtained at GWCI's second Cancer Survivorship Research Symposium, the paper summarizes the discussion amongst cancer survivors, caregivers, researchers, clinicians and other healthcare professionals. The goal of the symposium was to identify key issues for survivors and strategize about optimal interventions for improving care and support.

The authors outlined five key areas of need related to health care delivery system challenges: psychosocial impacts, health maintenance needs, employment issues and community-level barriers. They explored current approaches for addressing these concerns and made recommendations about interventions that may improve survivorship care and quality of life for adolescents and young adults.

"The symposium was a great opportunity for those within the cancer community to conduct high level conversations about the real needs of adolescent and young adult cancer survivors," said Mandi Pratt-Chapman, M.A., associate director of GWCI Community Programs and author of the study. "Our hope is that we will identify issues and come up with solutions that will address post treatment needs."

###

Additional authors include Anne Willis, M.A., director of the division of cancer survivorship; Jennifer Bretsch, M.S., CPHQ, project manager of the division of cancer survivorship; and Steven Patierno, Ph.D., adjunct professor of pharmacology and physiology at the GW School of Medicine and Health Sciences.

For more information or to interview an author of the study, please contact Lisa Anderson.

About the George Washington University Cancer Institute (GWCI)

GWCI takes a comprehensive approach to a complex disease. In connection with the GW Hospital and the Medical Faculty Associates, GWCI provides for collaboration in the study, diagnosis and treatment of cancer. Its mission is to ensure access to quality, patient-centered care across the cancer continuum through community engagement, patient and family empowerment, health care professional education, policy advocacy and collaborative multi-disciplinary research. More information about GWCI at: gwcancerinstitute.org.

About the GW School of Medicine and Health Sciences

Founded in 1825, the GW School of Medicine and Health Sciences (SMHS) was the first medical school in the nation's capital and is the 11th oldest in the country. Working together in our nation's capital, with integrity and resolve, the GW SMHS is committed to improving the health and well-being of our local, national and global communities. smhs.gwu.edu.

---

[ | E-mail | Share ]

?

AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

Source: http://www.eurekalert.org/pub_releases/2013-04/gwu-gci042613.php

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Gas prices fall 8 cents in past week in W.Va.

CHARLESTON, W.Va. (AP) -- Gasoline prices have dropped for the fourth straight week in West Virginia.

AAA East Central says the average price for a gallon of unleaded gasoline fell 8 cents in the past week to $3.58.

Prices range from $3.47 in Parkersburg to $3.69 in Martinsburg and Morgantown.

A year ago, gas prices averaged $3.92 in West Virginia.

Gas prices nationally also fell 8 cents in the past week to average $3.52 per gallon.

Source: http://news.yahoo.com/gas-prices-fall-8-cents-153704362.html

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Chicago Symphony Orchestra to play behind bars

CHICAGO (AP) ? It'd be enough to make Beethoven roll over in his grave.

Members of one of the classical music world's most celebrated orchestras will perform Sunday behind bars. Looking on will be celebrated conductor, Riccardo Muti (MOO' tee).

The concert in Chicago's Juvenile Temporary Detention Center is a culmination of a weeklong musical workshop for inmates organized in part by the Chicago Symphony Orchestra.

Muti has made community outreach a priority since taking the helm of the CSO in 2010. The goal is to inspire at-risk youth and impart greater appreciation for music.

The detention center holds mainly teenage boys awaiting trial on charges ranging from dope dealing to murder.

The works being performed include compositions inmates helped compose. Italian-born Muti will be in attendance but wasn't expected to conduct.

Source: http://news.yahoo.com/chicago-symphony-orchestra-play-behind-bars-175718220.html

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